Spatial Omics Solutions for JAK/STAT Signaling Pathway

Inquiry

The Janus family of tyrosine kinases (JAK) and the signal transducer and activator of transcription (STAT) family is a ubiquitously expressed intracellular signal transduction pathway. It is involved in many key biological processes such as cell proliferation, differentiation, apoptosis, and immune regulation. It promotes cytokine-mediated cell activation simply and efficiently.

Under certain pathological conditions, the inflammatory process is widely recognized as a local protective response when the body is exposed to pathogens or injury.JAK/STAT is also a major signaling pathway regulated by cytokines and is essential for initiating innate immunity, coordinating adaptive immune mechanisms, and ultimately suppressing inflammatory and immune responses.

How we use a spatial-omics approach to resolve the JAK/STAT pathway

The JAK/STAT signaling pathway is widely present in a variety of tissues and cells, and its over-activation is closely associated with the development, progression, invasion, and metastasis of many tumors. The JAK/STAT pathway has been the focus of CD Genomics' attention, both to unravel its mechanisms and to discover new clinical candidates.

Figure 1. Overview of the regulation mechanism of JAK/STAT pathway. (Ping, X., et al., 2020)

We can analyze intercellular signaling by modeling the JAK/STAT pathway activity estimated by gene expression in the spatial environment, thus integrating different types of views. This allows our customers to observe the spatial distribution of marker expression of interest, interactions within local cellular ecological niches, and at the level of tissue structure. to better understand multicellular processes, especially intercellular communication.

Key genes that we offer our customers to study

ACE	ACE2	AGT	AGTR1	AGTR1A	AGTR1B	AGTR2	ANGPT1	ANGPT2	ANGPT4
ANGPTL2	ANGPTL3	ANGPTL4	BDKRB1	BDKRB2	BDNF	CCL2	CCL5	CCR1	CCR2
CCR5	CLCF1	CNTFR	CSF1	CSF2	CSF2RA	CSF3	CSF3R	EFNA1	EFNA3
EFNA4	EFNA5	EGF	EGFR	EPO	EPOR	ERBB2	ERBB4	F2R	F2RL1
FGF1	FGF10	FGF14	FGF15	FGF18	FGF19	FGF2	FGF20	FGF21	FGF23
FGF3	FGF5	FGF7	FGF8	FGF9	FGFR	FGFR1	FGFR1A	FGFR1B	FGFR2
FGFR3	FGFR4	FLT1	FLT4	GAS6	Gh	GHR	Ghrh	Ghsr	Ghsr1a
Gpr135	HGF	HTR2a	IFI27	IFIT1	IFL16	IFNA2	IFNA4	IFNB1	IFNE
IFNG	IFNGR1	IFNK	IFNL1	IFNL2	IFNL3	IGF1	IGF1R	IGF2	IL10
IL12A	IL12B	IL12RB1	IL12RB2	IL13	IL13RA1	IL13RA2	Il15	IL17R	IL20
IL20RA	IL20RB	IL21	IL21R	IL23A	IL23R	IL24	IL26	IL27	IL27RA
IL2RB	IL3	IL31	IL31RA	IL3RA	IL4	IL4l1	IL4R	IL5	IL5RA
IL6	IL6R	IL6RA	IL6ST	INSR	ITK	JAK1	JAK2	KDR	KIT
KITLG	LEP	LEPA	LEPB	LEPR	LIF	LIFR	LMTK3	MERTK	MET
NAMPT	NTRK2	OB-R	OSM	OSMR	PDGFA	PDGFB	PDGFC	PDGFD	PDGFRA
PDGFRB	PIP	PRL	PRL3B1	PRL3D1	PRLR	STAT1	STAT2	STAT3	STAT4
STAT6	STYK1	TEK	THPO	TPO	TSLP	TYK2	VEGFA	VEGFB

Potential application areas

Rheumatoid arthritis
Parkinson's disease
Multiple sclerosis
Inflammatory bowel disease
Sepsis
Tumors and cancers (myeloproliferative neoplasms, cutaneous T-cell lymphoma, lung cancer, stomach cancer, prostate cancer, colon cancer, etc.)

We do it better

Current interest in the JAK/STAT pathway is focused on inflammatory and oncological diseases and related drugs. CD Genomics can reveal the role of the JAK/STAT pathway in the pathogenesis of each disease through spatially resolved genetic analysis or metabolic analysis to further understand the disease development. Describe the function of the JAK/STAT pathway in the stabilization of the internal environment and the mechanism of action of inhibitors. It may provide new therapeutic strategies and targets for the treatment of multiple diseases and provide new directions for drug development.

Reference

Ping, X., et al., (2020). "The role of JAK/STAT signaling pathway and its inhibitors in diseases." International Immunopharmacology. 80, 106210.

For research use only, not intended for any clinical use.