Spatial Omics Solutions for Akt Signaling Pathway

The complexity of cancer and the variability of its clinical features stem from its complex etiology involving DNA, RNA, and protein factors. It has become an important public health problem that affects people's lives. Although cancer research continues to increase and to some extent provides many new clues for the treatment of cancer. However, cancer treatment remains a major scientific challenge.

The PI3K/Akt pathway is an intracellular signal transduction pathway that promotes metabolism, proliferation, cell survival, growth, and angiogenesis in response to extracellular signals. Multiple studies have found that the PI3K/Akt pathway is aberrantly activated in cancer and controls core cellular functions such as proliferation and survival, playing a key role in cancer progression.

How we use a spatial-omics approach to resolve the Akt pathway

Akt is at the core of complex signaling pathways and is important in cancer pathology. It is one of the cellular signaling networks of greatest interest to CD Genomics due to its critical role in cell metabolism, growth, proliferation, motility, survival, and apoptosis. Its many important regulatory functions also make the Akt pathway a most valuable target for drug discovery.

Figure 1. The activation process of PI3K/AKT signaling pathway. (Xue, C., et al., 2021)

Key genes that we offer our customers to study

Potential application areas

• Insulin signaling (diabetes)
• Malignant diseases (gastric cancer, glioblastoma, pancreatic cancer, ovarian cancer, and breast cancer)
• Neurological diseases (Alzheimer's disease, Parkinson's disease, epilepsy, multiple sclerosis)
• Cardiovascular events (vascular remodeling, atherosclerosis, vascular injury, cardiac hypertrophy)
• Inflammatory and autoimmune diseases (systemic lupus erythematosus, rheumatoid arthritis)
• Pulmonary fibrosis

We do it better

While cancer is at the center of CD Genomics' solution offering. But we equally support many other potential diseases such as diabetes, heart disease, or neurodegenerative diseases. The Akt pathway is at a critical link and we allow to analyze genes in the Akt pathway by performing spatial scale analysis. Determining whether genes that are significantly aberrantly expressed have research potential in many cancers to develop effective molecular biomarkers. Improve early detection, monitoring, and prediction of therapeutic response in cancer patients.

Reference

1. Xue, C., et al., (2021). "Crosstalk between circRNAs and the PI3K/AKT signaling pathway in cancer progression." Signal Transduction and Targeted Therapy. 6, 400.