Spatial Omics Solutions for Immunology

Spatial Omics Solutions for Immunology

The human immune system often plays a role in the development and progression of different diseases such as autoimmunity, fibrosis, and cancer. Understanding which cell types, cytokines, pathways, and transcription factors are involved in the regulation between immune activation and suppression can better help researchers treat immune system diseases. And learn how single-cell and spatial omics are driving new research into autoimmunity, immuno-oncology, vaccine development, and more.

How we're using spatial omics to redefine immunology research

Traditional bulk expression and proteomic analyses in particular have the unavoidable disadvantage of losing due positional information in cellular fragmentation. CD Genomics offers the spatial-omics analysis of immune cell location in tissues to explore the immune system at multicomponent, single-cell resolution. It can be used for single-cell, high-dimensional immune analysis of human PBMC and whole blood. This provides a wealth of high-quality data that can enable our clients to better understand the pathogenesis of immune diseases, reveal differences between individuals, and be used to find new biomarkers and disease treatments.

  • Immune cell infiltration, gene expression profiles in different regions of immune cells.
  • Immune population spreading, spatial location resolution of different types of immune cells.

Acceptable sample types

  • Frozen tissue. Fresh samples are snap-frozen in liquid nitrogen pre-chilled isopentane and stored at -80°C.
  • OCT-embedded tissues. Fresh tissue snap-frozen in isopentane followed by OCT embedding, or fresh tissue snap frozen directly in OCT embedding at -80°C, with care taken to indicate sample orientation, and samples stored at -80°C.

*Sample handling and transportation processes need to be in a cold environment.

Our advantages

  • We can provide frozen section preparation solutions with higher consistency and more delicate experimental operations.
  • We offer high-definition bright-field and fluorescence field shot imaging solutions. Finer image information acquisition and stitching strategies to provide clearer images for omics of tiny areas within the sample.
  • We have an independent cloud analysis platform to solve the difficulties caused by the huge data volume, high-quality control requirements, and numerous analysis needs in the analysis of spatial group sequencing data, and to complete spatial group analysis quickly and customizable.
  • We can meet the needs of RNA-FISH validation of genes of interest in analysis results and high-definition imaging of tissue sections for immunohistochemistry to obtain expression and localization information.
  • We provide one-stop service from experimental design, spatial information tagging, library sequencing, and customized analysis.
  • Our experienced experimental team ensures a high degree of sample consistency and provides a personalized interpretation of product application scenarios, maintaining a focus on the biological significance of immunology and the immune system.
For research use only, not intended for any clinical use.

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